FYI if you cut down the TVL to a few really trusted vendors, like many users do, this increases security a little, and increases false positives a lot.
If you run "Unrecognized" restricted in the sandbox, you are safe for sure. I have even set it to run Virtually and added the extra option to "Run Limited" to the rule. I feel safe. This means that programs have a half decent chance of running so I can see what they do in the sandbox. With OSArmor there and AppCheck, I feel like it's safe.
Trimming the TVL is great for learning the program, but it's not really an improvement on protection, considering Cloud Lookup has to be turned off too. At least, if you don't want Comodo adding vendors to the TVL every time you install a program from a vendor you removed.
I think the best solution is to run Comodo for about 6 months, save your settings, and then uninstall and reinstall the latest. The update process is still rough for sure. I haven't ever experienced a loss of settings from an update, however, and I don't think it's a common thing.
I would say the biggest thing to look for would be something like->install Comodo Internet Security Essentials during installation of Comodo->remove CISE because it doesn't do anything->Comodo main still wants it->"error...Comodo must be reinstalled"...this kind of thing. I really don't like the CISE element of the program. Appears to break things to me. Still, I think Comodo has very few bugs under the hood. When there is a problem, protection doesn't quit...at least as far as I can tell. Like an old car with low miles LOL...