Works great.
This comment is about Office exploit protection in general, not about ConfigureDefender:
I have a certain Word add-on, "SaveReminder Ver 2.1.dotm", it lives in the Word startup folder in Appdata/Roaming/Microsoft. After enabling Office exploit protection, I got an error message when opening Word, saying that the file was blocked. Okay fine, but when I open the exceptions tab to fix the problem, I discover that the add-on file is gone entirely. It is not even in WD quarantine. Cute, huh?