I run DeepInstinct with Cyberlock (fka Voodooshield) on primary win10. I have not used Crowdstrike or spyshelter. Depending on how spyshelter runs, DeepInstinct might block it and you might have to create an exception to install & run it. DeepInstinct is fast, smooth and very quiet on my computer.
PS if spyshelter is also a firewall, I would not run it with DeepInstinct.