Notify me only when programs try to make changes to my computer
Real-time security
Windows Defender - for now(until ZAM 3 is out)
Comodo Firewall w/ HIPS Disabled
Appguard v4 (Lockdown) - minimal configuration
Sandboxie
SMADAV - use pen drive a lot
Firewall security
About custom security
Comodo firewall - CS setting, once everything is set ticked trusted application/installers
Appguard - few modification as per needed basis
Syshardener
Nothing has change much already put a lot of trust on this protection a few year ago, malware isn't an issue... rather focus on other things that matter most (family, work, etc...)