Pick one program that you think provides the best protection if it was the only one you could use.
For me I think either Appguard or Voodoo Shield would be pretty much bullet proof.
One program can be the only thing you need, in business context the PCs only have one solution install, maybe exist other solutions for administrators to scan a machine when some suspicious is detected, but the individual machines work with an individual solution.
I will not trust my safety of my particular machine to Appguard or Voodoo Shield, no way Jose. I trust my security to brands that have a name and a history in the security industry, in my case Kaspersky, but Bitdefender, Eset or F-secure are great solutions for a home context.
Personally, to my friends, I always recommend having a second solution besides the main AV, something like Malware bytes free, Star emergency, in my case Hitman pro, for a second opinion.