Why manual updates ?
You could add an additional on demand scanner such as Zemana Antimalware.
Consider replacing AdBlock with u Block Origin.
Consider some type of data & system backup solution.
Thanks for sharing your config
Hey, thanks for sharing your security config
It would be nice to have Zemana and Emsisoft Emergency Kit as on-demand scanner apart from what you currently have
For browser extensions, it would be great if you could add HTTPS Everywhere and Privacy Badger. Both products are developed by Electronic Frontier Foundation. They are available for Firefox, Chrome, and Opera for PC and HTTPS Everywhere is available for Firefox on Android as well.
It's also important to have strong and different passwords for different websites. You might consider open source password managers like Keepass or KeePassX or PasswordSafe.
Also have a backup solution. Either manual or a software.