Here is how I have set up a few machines for people I know. This is one of the lightest setups that you could have, also very effective at stopping a large amount of malware. Everything is free except Zemana which fairly cheap for what it does. If you were to get an infection with this setup, it's very likely you would have to had disabled something. I set this up for some family who were prone to infections a few months ago, they have not since contacted me to help them fix anything. Where they would usually call me once a month to help with something...
Zemana Premium Realtime protection main AV, with pandora activated.
Tiny Firewall -- Addition to built in firewall.
Ublock Origin -
Fan boys Ultimate list added.
Ghostery - Set to block All trackers & cookies
Voodoo Shield - to help with unknowns.
Firefox main browser
Self destructing cookies Browser Add-on
Bluhell Firewall Browser Add-on
Privazer to clean up.
Ccleaner to manage startups and scheduled task.
Patch My PC To keep software up to date.
Destroy Windows Spying To keep your privacy in check.
Here are a few on-demand tools to run, to make sure you are clean as well...
Adware Cleaner
Adware Removal Tool
Junkware Removal Tool
Zhp Cleaner
9-Lab Removal Tool
Eset Online Scan
I hope that you can use this information to help you along the way.