Umbra: I'm using MBAM as my realtime AV with Sandboxie and Privatefirewall but of course with common sense however I'm not advise to do my setup as risk are still exist.
Indeed since its design to detect threats that are not caught by other realtime protection but of course those combination are experimental and with experience.
I will have to agree with other statements, MBAM is not a full AV solution it is only a helper to your AV. If you want to use Comodo, then use the full suite. Or you can use MSE, Avast, Avira or what ever other good AV you want to use. This video does not paint a complete picture, you have to consider all of the vulnerabilities found in Comodo v.6 and how MBAM doesn't detect a lot of malware. Of coarse if you use UAC and never download unknown files or visit unknown sites you could probably get by safe just using Comodo Firewall + MBAM but I would not recommend it.
MBAM's detection rate are really outrageous since most threats even digitally signed/PUP/ are able to determined from its analysis that other AV's couldn't and just bypass easily to be undetected.
Its like more than an hourly updates, almost perfect but not at all.