Of the two that you include in your pole - Webroot and Panda - I would choose Webroot because of some of its advanced features.
However, those advanced features, e.g. "rollback," may function too late to protect your data. In other words, the malware may have transmitted data before rollback reverted your system to a pre-malware state.
Webroot is not going to protect the "click-happy."
For best security, create a default-deny protection scheme.
Currently, Kaspersky has the most user-friendly incarnation of default-deny. Next would be Comodo Internet Security.
Although one can achieve the same using softs designed specifically to create default-deny: NoVirusThanks Exe Radar Pro, AppGuard, VooDooShield, Faronics Anti-Executable... are the ones that come to mind.
Default-deny provides maximum protection in "lock-down" mode. Some users find this unacceptable since some apps won't work properly, or automatic updates will not work (no big deal really - very easy workaround), difficult to configure, etc.
Like I said, Kaspersky avoids virtually all of these issues.
NOTE: Beyond critical softs vulnerabilities, I consider malicious scripts to be the next most serious security problem. The only effective means that I have found to stop these sneaky little buggers - the ones not detected by signature - is default-deny.
Considering that malicious script detection via signatures is an exercise in utter futility - one can readily see the real advantages of default-deny.
Default-deny is not ideal for someone who likes to always install new softs; it works really well for someone who configures their system and makes few, if any, changes.