Learn Yourself, Use Ccleaner, its more than enough. I myself Dumped the rest all software licenses and now experiencing a clean system with only CCleaner.
LOL. I am computer engineer for about 15 years, don't wont to even start about my education. I learn about your expertise from your answers, and from them I see you should change your profession. TuneUp is one well written and organized piece of software, in it you can find everything you need under one roof. From my vast experience about system tuning my vote easily goes to it.I'm a computer technician 4 years and i know what i'm saying. I dont care if you are TuneUp's fanboy, but i'm not. TuneUp sucks because free alternatives can do same task much better and without any problems. If you are noob that's not my problem.