If one wants to use it with H_C, then there is a predefined setting profile for that, that allows EXE files globally: Windows_10_Avast_Hardened_Mode_Aggressive.
It can be an interesting combination for some users. NVT ERP will cover the EXE files, and H_C will allow EXE and take care of the rest. If the EXE application installer is blocked by NVT ERP, then forced SmartScreen (the H_C feature) can be used to safely install the application.
NVT ERP can whitelist applications by the Signer, which can be sometimes more convenient as compared to SRP whitelisting in the home environment.