Thanks for sharing and welcome.
The fellas above covered it, if your not a big fan of Ublock you can sub that for AdGuard, which is system wide
protection.
Please enable Smartscreen and UAC (preferably, to maximum). You are only using Windows Defender, these layers are even more important.
Add Zemana Portable, ESET is not the best on demand scanner at all.
Last but not the least, be cautious!
Enable UAC & Smartscreen.
ESET as an on demand scanner? Eset online scanner?
Anymore on demand scanners?
Please edit your config with more thorough details.