Hi and sorry for the late response.
When i downloaded 360 i blocked the PromoUtil.exe. (i think thats the name) process that is responsible for generating ads with Windows Firewall.
All the engines enabled.
USB Drive Protection and Online Shopping Protection turned OFF. If you need any of these you can have them on.
From the settings you can enable/dissable any option if you dont like it. I've enabled the Patch before you turn off PC and ticked everything in the Full Check section.
Cloud Analysis OFF
From Active Protection i didnt touch anything. Dont use 360 extensions, there are better options. I use Chrome with HTTPS Everywhere and Ublock.
Trust list: I added the exes from Comodo installation folder.
COMODO Firewall: i installed only the program, no geekbuddy or comodo dragon.
Then you switch to Proactive ->Restart PC.
General Settings: pretty much default
Firewall: Safe Mode, Do not show...OFF, Enable Trust...Unsecured...ON, Turn traffic animation ON(they are so cool!!), the other stuff OFF, from Advanced section everything ON.
Application Rules: I added every active 360 process as Allowed Application.
Everything else Default.
HIPS: OFF
Containment Settings: Turn OFF the things above Advanced. In the Advanced turn ON Do not show privilege elevation alerts(Block).
Auto Containment: OFF
File Rating: OFF
Advanced Protection->Virus Scope OFF, Script Analysis OFF, Miscellaneous Default
Website Filtering OFF
I forgot to mention that i have the modern theme, its so clean
Final words:
1) Even if you have the best Av, common sense is what matters.
2)If i need to run an unknown program i always check it Virus Total. If im still suspicious ill run it in Comodo Sandbox( thats why i downloaded in the first place).
I hope i helped!