1 When you move into the higher resolutions, everything gets pretty small, so you will probably need to increase scaling. Some older programs don't scale well, so make sure you don't have a mission-critical program like that, or you might end up disappointed.
2 With most curved monitors you need to sit right in the middle to get maximum benefit, so make sure this is comfortable and practical for you. Some monitors offer a slight curve so you have more freedom of movement.