Have you ever had one of those dreams where you realize you're dreaming and then you wake up, but you just popped into another dream and you bumble along until you realize you're dreaming again and you just can't get out, well that's my approach to desktop security. What I like to do is layer my sandboxes one on top of the other for maximum security. I'll run a vm, within a vm, within a vm, then sandbox the browser with sandboxie, and then chromes own sandbox runs inside that. That way if a malware author pops the chrome sandbox he wakes up into sandboxie, and then from sandboxie into my desktop vm software over and over and over.