I'm repeating what I tell everytime: default-allow software IS NOT RELIABLE. It's a good companion for a default-deny solution. The moment you choose to rely on a defaut-allow software, however good it is, you're doomed.
For example, in my main PC I use Kaspersky Internet Security, configured to default-block all files that are not digitally signed by a Kaspersky Trusted Vendor. In my secondary laptop, I use Windows Defender, configured by ConfigureDefender, and Hard_Configurator set in "Disallowed" settings which will block everything by default, except specified files (of course it automatically whitelists critic files).
I wouldn't dare, EVER, to trust 100% on a default-allow "security software". That's playing a bet. Maybe it protects, maybe it fails. Not worth the risk.