This will be completely out of the box and I might sound silly.
I myself do not like using antivirus for normal daily usage for CAD, CNC, gaming, photoediting, or videoediting.
When the need or concern arises for malware and protection, downloading torrents, or when I am testing malware, my ondemand scanners is turn on, Thanks for CrystalSecurity and Xvirus and their portable versions, Turn it on when I need them.
Zemana are a good choice for ondemand scanning and if you are not gonna have it run 24/7, the free version will be just fine.