Comodo is a toy for those who like to manually control every change in the system. It does not have a full-fledged web filter, there is no IP filtering by reputation, and also there is completely useless antivirus engine. Yes, it probably provides better protection of the system from damage, as well as better protection from ransomware if it is configured correctly, but in terms of protecting personal information from complex threats, I think it is completely useless.
F-Secure is quite a convenient solution from the category of install and forget, but I don't really trust this antivirus because of weak self-protection, as well as a rather weak Avira engine, for example, I sent them at least 2 threats for mac, although they had a good detection on VT. The advantage is impeccable privacy and the presence of a banking mode, although it looks less powerful than, for example, Eset banking mode.
Symantec is powerful and flexible, it can be configured for maximum protection, or it can be made completely invisible in the system, I think that it surpasses competitors from your list in the average scenario