Here is one not especially useful, but probably a true answer to your question.In your opinion, which is the most powerful antivirus ever?
what is AMSI ??The most powerful should be Kaspersky (the best is subjective); it doesnt have any weakness in this protection arsenal.
Strong signatures, very good heuristics, AMSI support, competent and fast cloud protection, best in class emulator and behavior blocker, strong modules like application control and trusted application mode.
why Mcafee ??My opinion Kaspersky, Norton, Mcafee and the most powerful is common sense. Do not enter rare places
what is AMSI ??
The Windows Antimalware Scan Interface (AMSI) is a versatile interface standard that allows your applications and services to integrate with any antimalware product that's present on a machine. AMSI provides enhanced malware protection for your end-users and their data, applications, and workloads.
AMSI is agnostic of antimalware vendor; it's designed to allow for the most common malware scanning and protection techniques provided by today's antimalware products that can be integrated into applications. It supports a calling structure allowing for file and memory or stream scanning, content source URL/IP reputation checks, and other techniques.
AMSI also supports the notion of a session so that antimalware vendors can correlate different scan requests. For instance, the different fragments of a malicious payload can be associated to reach a more informed decision, which would be much harder to reach just by looking at those fragments in isolation.