Going signature less & striving for bullet proof protection...try Comodo or anti-exe or kinda software...
Kaspersky - System Watcher & Application Control are effective & automatic, good offline too
Bitdefender - Active Threat Control is quite effective & automatic, good offline too
Emsisoft - Its kinda semi/lite HIPS...popups like startup entry, direct disk, another process, etc..., same popups offline too
Norton - Sonar is effective, average offline