Overkill has a very different meaning for many people and even for one man when using two computers.

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Personally, on Windows 10, I would not recommend any combo enumerated in the poll, for possible compatibility problems (broken updates, BSOD, hidden software incompatibility, etc.). You can use a third-party combo without issues for months, but there is always a matter of time when it fails. Why?
Windows 10 is evolving too quickly for third-party developers.

It affects especially the free versions of paid software, because the free is always adapted after paid.
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But anyway, on my father's
old XP computer, I installed:
Comodo Firewall (CS settings), Sandboxie (paid), Shadow Defender (on boot).
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In the above setup Shadow Defender + Comodo Firewall protect the system disk. Sandboxie high customized sandboxes allow using and updating software installed inside sandboxes on the secondary disk. Furthermore, I do not consider that config as overkill, on that computer, with my father in front of it.
