I'd first learned about, and used,
Sandboxie
upon first becoming a member here on MalwareTips.
It was originally developed by a gentleman named Ronen Tzur to address the vulnerabilities present in Windows IE hence Sandbox-IE.

Having also learned about alternatives such as Comodo's Firewall w/auto sandbox & Shadow Defender, I've used and happily recommend each because, in most applications, they work. Sandboxie had been my long time favorite, while it's notices can seem a bit inconvenient, usually (as UAC in Windows) most times they represent actions user initiated w/the advantage being sandbox containment. SBIE does not function currently on my wife's newer HP lap top, yet as
@simmerskool, I've not moved to track down the reason(s) why which is the nature of software with hardware, & reflects no lack in the (overall) consistant reliability of either. I was very pleased
tonibalas mentioned
Shadow Defender
although I do not malware test, it's a remarkable <reset> button that's simpler than a "sandbox". It has been seamless and (from my own experiences) the most user friendly of all choices mentioned above. "Shadow Mode" has become my family's alternative of choice, the main advantage being that it protects the
master boot record (MBR) the boot sector at the very beginning of partitioned computer mass storage devices (Wikipedia).
@SearchLight, thank you for beginning this thread! After reading the posts thus far I've another (nearly forgotten) choice, and shall be revisiting Comodo's firewall w/auto sandbox ..which will subsequently disappear if I do it in Shadow Mode,
lol!
