Both are good, this is though choice..may I ask why you created this pool? is this question made because you want to use one of them? if you are an advanced user and know what are you doing you could go for CIS, but if you don't want get confused by many pop-ups and can't decide which one is False positive then you would go for Avast. Avast is quite good and it's free
One of the staff here on MT (Umbra Polaris) said, there are 2 types of program, the one is the complicated one with many configurations but you need to tweak it (CIS) in order to get the maximum security, or the other one is the simplified one that almost no configuration but
common sense needed to get the maximum security (most of AV) But again..if you are an advanced user then perhaps you don't need CIS anymore since you know what are you doing
The great feature on CIS is it's firewall, it's Av engine it's not good as the others (at least for now)
CIS is quite good, the main purpose of CIS is "Prevention" not curing or removing malwares, and yes you can get your computer with malware free if you use CIS and tweaked properly
Regarding your question, my vote goes for Avast with Comodo Firewall, but since you were asked only Avast or CIS, then for the sake of simplicity I'd vote for Avast