Whether or no you trust Comodo Sandbox,Sandboxie,etc. you should only test malware in a Virtual machine or a separate testing machine.
Hopefully you will not go back to that practice.
Your on demand scanners are the same as your real time protection?
Consider using Zemana as an on demand option and or add some additional on demand scanners.
I would seriously consider adding some type of system backup solution.
Macrium Reflect & AOMEI Backupper both offer good free versions.
Thanks for sharing your config