Answers below. These are just my impressions at the current time:
With CS' settings in CF, does ViruScope option need to be enabled? Is it adding anything to CS' settings?
No, it doesn't do anything at the present time. I leave it on, because Comodo use the Recognizer in VS to gather information on malware behaviors. It isn't even functional. Viruscope has been on a VERY slow development cycle.
2) If I disable HIPS, will this also disable "Protected Data Folders"?
Yes. You can verify this by going to Settings->HIPS settings->Monitoring settings (just below Enable HIPS). You can see the Protected file/folder setting is there, so it is HIPS that monitors them.
3) Website Filtering? On? Off? Does this option add anything relevant to CS' settings?
Haven't ever seen it do anything. Another Comodo project.
4) Enable or disable Cloud Lookup with CS' settings?
If you use the standard Trusted Vendor List (aren't relying on your own changes to the list), then leave Cloud Lookup on. It's actually fairly powerful, and I think where Comodo will focus improvements.
5) I can understand CS' opinion about "CF is enough, doesn't need an AV or AM". However, what about browsers? How to deal with phishing, scams, fake websites, tracking, spying, privacy issues etc? Don't we need an AV or AM to take care of this browsers garbage and other online-dangers?
A-V-I use an a-v with Comodo in case I make a mistake. The Comodo sandbox will tell you that Comodo doesn't like the app or that it isn't signed or is signed improperly. However, if anything gets by that a good a-v will help. Personally, for free Avast is probably the best for this because of the internet blocking it does from the program. Don't' forget that Avast free is has great features and protection and the use of the cloud is intense for a free a-v. The companion browser extension is extrememly good too. Bitdefender Free is just plain amazing detection. I think the internet protection is even better than Avast (detecting bad sites/bad downloads), but I am not sure about this. Haven't had a chance to use BD Free, and I am going from memory of a video review. Just can't recall if it was Free or BDIS.
Browser-Use a good content/ad blocker like uBlock Origin. If you really want to go all the way, you can run the browser contained by clicking on the Comodo widget to start it. Avast has a very nice content advisor browser extension, also.
As for other malware, Comodo is supposed to have your back with script monitoring. I'm not sure about this, and I am hoping
@cruelsister will test Comodo against command line reliant malware with only the command line heuristics module enabled. Until the time this occurs, I will be using NVT EXE Radar Pro. However, Avast hardened mode set to the highest will block alot of malware activity. VoodooShield Free could be a good lightweight replacement for NVT ERP if you are worried about scripts. Comodo + Avast will be very good though...