If @mickel1 said "I use Comodo Internet Security", I would understand, since it has an Antivirus that replaces WDA and VirusScope is pro-active protection on top.
VirusScope is not an actual Antivirus. It's behaviour-based technology that cannot determine a definite threat, or based of a suspicion. It monitors certain criteria of the processes, but only after it's already running in an isolated environment. A known threat would have been picked up by the resident AV - if one was installed.I can't see a strict use for signatures when you have automatic sandbox for unknown files + Comodo Viruscope
VirusScope+A/C is only useful for undetected threats, it cannot perform scans like a traditional malware scanner.Viruscope is a behavior analysis technology built into Comodo [..] that monitors the activities of sandboxed processes and installers and alerts you if they take actions that could threaten your security.
Viruscope is another key layer of security [..] Our real-time virus monitor protects you against known threats, while auto-sandboxing protects you against unknown threats. With Viruscope on top, you also get proactive warnings about brand new malware.
Source: Viruscope – Feature Spotlight, Computer Protection, Comodo Cloud Antivirus | COMODO