i have to put you "at risk" because you disabled most Windows built-in security (and uninformed beginners may do the same). However i won't rely on Comodo anymore to protect me
Granted, however after prolonged use of Windows UAC and/or SmartScreen in Internet Explorer (ever since Vista, it's been 10 years!), and now globally in Windows 10, I have deemed them unnecessary for my case.
Perhaps you are right, one day I might regret it, but I do not see that happening any time soon: I have stopped testing software on my main machine (virtual machine or otherwise), which is the primary purpose of protection for SmartScreen and/or UAC. Also, in my opinion, Windows built-in components are unrelated to my choice of COMODO or any realtime security software I might have running, so any comparison is unnecessary.
Again, it might not be a wise choice, but I have valid reasons to believe that UAC/SmartScreen, while obviously not completely useless, are also not "miraculous" - they will not necessarily make the difference in my config.
I consider the probability for infection rather slim, due to the combined factors of my computing habits and the purpose of the computer on which I have installed this PC (gaming/graphics/coding/etc).
I already have taken into account the possibility of exploits, browser drive-by downloads/infections, malicious game servers, and have taken precautions for those cases, as I'm constantly on guard for any such malicious activity.
Thank you for noting these specific aspects of my config, I'm grateful you took the time to read my updated version,
@Umbra!!