You might want to take a look at the settings changes in the latest version of v10. They aren't well documented around the net yet. The biggest ones are in the Advanced Protections->Miscellaneous header. Previously, heuristic command-line analysis settings were in the HIPs section. Some executables (and malware) may depend on embedded scripts, and Comodo turned off most of the protections for embedded scripts by default. This is because some users were seeing a new pop up for the same activity every time they performed the action. Happens when a randomly named temp file is created by a process in order to run a script.
I turned all of the protections on and only have one recurring script. I am used to dealing with the issue, so it's not a problem for me. Others may want to test with the settings on to see if they have a problem. If you do get the repeating pop up, you will also get a new file in the file list and then a file will be created in the path C:\ProgramData\Comodo\Cis\tempscrpt. If you allow the behavior (if you know what caused it and it is safe) but uncheck the remember setting option, you will only have those two issues. Otherwise, if you remember it, you could end up with other references to the file in the "Unrecognized files" area/folder accessed from the widget and maybe in HIPs.
I just "forget" the choice each time and empty the tempscrpt folder once in awhile and then whenever I think about it purge the file list of files that have been removed from the system. That gets rid of them there.
Thanks. Just had a look in there and adjusted the settings accordingly.
The need to try to cover as much found left undone from a previous version is a good choice of course. Test for complications (if any) etc.
Absolutely take a look at cruelsister's settings. She relies exclusively on the sandbox, and it is bullet-proof:
Video Review - Comodo Firewall 10 Setup
If you want that protection but also prefer to know more about what is happening on the system, the HIPs are awesome for that and also the script blocking functions.
I am liking CFW more and more too but it can still be improved. 10 is a big significant improvement over 8 even seems more or less universally accepted. Best thing for me is the ability to control the internet. Block and remember...that's what I do with apps and the net...

Those special settings and confirmed testing's by her are very convincing enough for me too I agree wholeheartedly.
Putting CFW 10 through a few of my own preliminary metal tests (per cruelsister's rules) has not disappointed in the least. In fact solid.
Not at all familiar with version 8 so have no idea how comparisons stack up between them but it's simple enough to read through other's results and see how and/or where they differ.
The added idea behind HIPS which was a welcome development when in their first infancy was it's featured ability for users so inclined to learn some of the intricate behaviors and interactions the program encountered as signals were launched then instantly interrupted, where the user could trace origin/destination location paths/types of files/extensions etc. (the list goes on as evident in CFW) and basically get a better feel so to speak of their own machines.
For me it was a honeypot of the highest order.
Collecting those bugs after rendered inert, copy them, and safely set them apart for further study.
The security aspect of strengthening the CFW sandbox/auto-containment feature is to a HIPS devotee like me, a best dream come true.
For the time being until I get a bit farther along with it's many other good points for security the sandbox alone is proving quite a force field.
I can recall some time ago with 32 bit HIPS where that very thing was being tested but not sure if it was ever fully implemented before 64 bit knocked them out of contention for the most part to what we have today.