So, you would be probably wrong. It is as true as saying that any human is just a mammal.
I will try to explain my experience with AppGuard (I was a beta tester for some time).
Appguard is designed for semi-static setup. You can adjust it to get no alerts, but this is not a task for an average user. If AppGuard is properly configured, then the computer protected by AppGuard can be used by the average user. People who install frequently new applications will not be happy, as you could see by yourself.
If you will try to run something from the folders normally available to non-admin user (for example from the Desktop, USB drive, etc.) then it will be usually blocked (scripts, unsigned programs) or restricted, to prevent the infection of System Space. The restrictions are similar to sandboxing (with memory and registry guard) because they are automatically applied also to child processes. This is the first layer that can protect the system.
The second layer includes Guarded Applications installed in System Space (web browsers, Office applications, media players, webmail clients, etc.). They are restricted similarly to those from the first layer.
There are also other features like: IstallGuard (for MSI installers), ProtectedFolders, Publisher List, Power Applications, TamperGuard, Privacy Mode, Privacy Folders. The full info can be found in AppGuard manual:
Generally, AppGuard is suited as a companion to any AV, and this is strong protection against all kinds of malware (including fileless).
I hope that @Lockdown (former MT member who worked for AppGuard) forgive me if I missed something important.:emoji_pray: