One advantage of some of the best protection suites is system protection. Aside from the anti-malware/anti-virus aspect, some of them do a great job looking after sensitive areas of Windows. This is helpful in regards to the performance of the PC long term. I don't know personally, but I imagine Kaspersky will provide excellent system protection. Comodo is bullet-proof against malware if the user follows the advice of prompts, and they are generally very good and apply the correct pressure. Not going to get system protection to speak of, though. HIPs helps with this, but Comodo's HIPs don't compare to the system-wide protection of even 360 Total Security...the only BB I can speak for at this point. Fairly sure Kaspersky will beat this and I think Emsisoft will surely beat this, too.
If you want HIPs, you can add HIPs with ReHIPS or something. Not that Comodo isn't good. Looking under the hood, the program is even a dice clever. I admit this surprised me some. Comodo devs have done a good job of thinking things through in a number of meaningful ways. Beyond this though, Kaspersky gives a different flexibility that might be more valuable if you can only choose one, and if you have money to spend. This is close, and I thought after using Comodo Firewall for a few days that this version might be an alert for companies like Kaspersky. Not that they will lose anyone over Comodo, but what about 2 versions from now, when the settings are all understandable by anyone and linked conveninently.
Kaspersky but Comodo is on the map for home use. Not sure where they are with their enterprise products.