I would not depend upon Comodo AV for anything but malware older than 4 weeks...
To me, for the typical user, it is better to prevent malware from getting onto the system in the first place; the AV and web protections should be equivalent to, if not stronger than, the sandbox module in terms of quality of protection.
All this is debatable...
Is there any AV's free or paid that would be strong enough to prevent most malwares from reaching the system?
I always thought the best bet was Avast w/settings, Comodo w/settings. Also Qihoo.