Nothing much has changed from last years config. 

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Sadly yes as iCloud Private Relay prevents NextDNS from filtering on Safari. So it can only block In-App-Ads on my device..With NextDNS, do you still need Wipr?
Well it's working alright I guess. You can add exclusions for apps and websites. Still, I am not so sure if I should keep it activated. Will see if I can get used to it.It reduces the attack surfaces and makes it harder for attackers. But, is your phone still functional?
Thanks for sharing but I got all the infos while enabling Lockdown Mode. I mainly wanted to try it because of the Safari restrictions and how it affects day to day browsing. So far it’s working alright I guess. But I’m pretty sure that I disable it within the next few days.Found that:
About Lockdown Mode - Apple Support
Lockdown Mode helps protect devices against extremely rare and highly sophisticated cyber attacks.support.apple.com
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