Hey Andy,
I was referring to browsing and docs mainly, not setups. However remember that if a malware accidentally run in the sandbox it cannot make damages in the host machine but the problem is that it could connect to internet (this is why is important firewall and network protection).
Understood.
The problem with the Internet, can be solved for applications which do not need it (document editors/viewers, media players, etc.). They can be opened in the separate sandbox, with the blocked Internet connection and some other important restrictions.
On Windows 10, the SmartScreen can be used to check if the installer is OK (files downloaded by the web browser).
For the simple software configurations the free Sandboxie version should be enough. For more complicated configurations the paid version will be required because of the free version limitations (one sandbox may be used at once, and applications cannot be forced to run automatically in the sandbox).
The problems with system incompatibilities can be avoided when using the wireless Internet with a metered connection.