Hi! Thanks for sharing your config. There are some things you could change to improve your security.
Regularly create system image backups. I understand you have backed up important files, but a system image backup is important so you don't lose your programs or settings. Not only this, but a couple of files could go past that you may not have thought as important before, but that you now need. If you have a NAS, creating a system image backup every month or so shouldn't be that difficult.
Make sure Windows Defender is configured for maximum security. (Block on First Sight, etc.)
Add some other second-opinion scanners. Consider Zemana Anti-Malware (Portable) or Norton Power Eraser.
Thanks for sharing
Formatting and reinstalling Windows in case of problems can be a choice but not the best one, because however, this implies to download the latest updates or patches with a great loss of time.
The best solution is to create one or more updated OS images using for example Macrium free.