Real time protection
If you want to increase Comodo Internet Security protection, you can use this guide : http://malwaretips.com/Thread-Guide-on-how-to-install-and-configure-Comodo-Firewall
On-demand scanners
Hitman Pro (Trial start when you actually remove infected objects.) -
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An on-demand scanner using multiple anti-malware engines and cloud technology. It offers unlimited free scanning but once you use it to remove detected malware it switches to a 30-day trial version. I recommend using it after you've scanned your hard-drive with the other products you have installed
Malwarebytes Anti-Malware Free (Free) -
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Malwarebytes Anti-Malware Free utilizes Malwarebytes powerful technology to detect and remove all traces of malware including worms, trojans, rootkits, rogues, dialers, spyware and more.
Virtualization:
I don't know if you tried Sandboxie , but you can give it a go , as it's a great program.
Sandboxie (Free/Paid) -
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Sandboxie runs your programs in an isolated space which prevents them from making permanent changes to other programs and data in your computer.
Always run suspicious of freshly downloaded files in a Sandboxie to verify that he download isn't compromised!Sandboxie will replicate perfectly your operating system so all the files should run without any problems in it.