It would be easier to apply the setup as follows:
- Run WHHLight and apply WDAC with your preferred Whitelits (for example include Program Files and Program Files (x86)).
- Use H_C Recommended Settings + preferred LOLBins + any adjustments you want.
- Use ConfigureDefender MAX settings + FirewallHardening H_C Recommended settings.
- Do not run WHHLight, because it will restore the initial settings.
In this way, you can get your setup and ability to manage it via H_C (except WDAC policies).
The folders whitelisted in UserSpace by H_C (%ProgramData% and %UserProfile%\AppData) are automatically protected by WDAC ISG.
The rest of UserSpace (including Public and Downloads folders + Documents/Images/Music/Video folders) will be automatically blocked on any partition.