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SpyShelter is not used by very many people on this site, but @Lockdown seems to know it pretty well, and has said some good things about it.
I can say that it produces a lot of prompts, it is not cheap, the support is not super friendly, and it has its quirks... but after all is said and done, it is strong protection! No security soft that I have found yet is perfect.
Ask @Lockdown about SpS. I haven't used it recently.
SpyShelter in the right hands is more powerful than any internet security suite could ever be.