Spybot was good when I had it on my very first laptop and nice. Now there are other time but I like the GUI even though and I will try it once it's out. If I am not wrong there is a portable one (or?) so I will try it out.
I remember using Spybot to clean my first computer back in the nineties. (i know i am just a pup compared to some of you) I love the name, Search and Destroy, makes me want to use it just because of that.