As long as you can interpret the pop-ups correctly you are protected. The auto-sandbox is there to reduce the number of HIPS pop-ups and to provide a certain degree of automated protection. One thing I do not like about the auto-sandbox: clicking don't sandbox again puts the file in Trusted, if I am not wrong. A user runs a malicious file. Signatures and the blacklist fail to protect him. The auto-sandbox limits the right of the process and the program appears not to run properly because of this. He clicks the Do not sandbox again link. Now he only has CIMA to protect him (if not disabled in settings).