What is the difference between Sophos Second Opinion vs Hitman Pro?

Well like other on demand scanners, they will provide the so called in-depth analysis detection; it is all about the effectiveness on removal of threats besides detection capabilities.
 
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It looks like Sophos Clean is targeted towards enterprise endpoints. Maybe they'll integrate both HMP and SC into one tool.
 
There's no difference

" Sophos Clean and HitmanPro use the same license. You can scan for free ALWAYS, cleaning is free for 30 days. Cleaning after 30 days requires paid license. Same for both products."
Source: Hitman Pro Support and Discussion Thread

" > Sophos Clean and HitmanPro are two different products or two names for the same product?
> Two names for same product."
Source: Hitman Pro Support and Discussion Thread