I used TuneUp Utilities earlier but then i found out that most of it could be done automatically with Windows tools, so i decided to use those instead.
My arsenal:
- Windows 7 Disk Defragmenter
- Windows 7 Disk Cleanup
- CCleaner
- SyInternals Autoruns, Process Explorer
- Group Policy
Defrag, cleaning, backup, Hitman Pro scan and MBAM update is done weekly through Windows Task Scheduler (So i don't have to do anything myself
).
I use Group Policy to apply tweaks like disable autorun, search from the start menu etc.
I don't clean my registry.