Hello,
On my system Glary Utilities Pro 5 added a lot to startup load; it really should be disabled.
Wise is lighter on my system.
I only use the registry cleaners if I am trying to track-down orphaned post-AV uninstall reg keys - you know, the kind that make the next AV product install fail. Typically, I only delete the AV keys.
Wise will find things that Glary does not - and vice versa.
If you compare them all...SlimCleaner, Advanced System Care, CCleaner, Glary Utilities Pro. Wise Care ... they all do about just the same.
I do like Glary for its GUI, but I also like Wise.
There is no clear-cut advantage of one over the other, so it comes down to personal preference of the GUI and how info is presented.
Sooner or later, if you're in the AV software evaluation and testing game long enough, you eventually reach a point where you've studied-up on the registry and you're knowledgeable enough to use regedit without demolishing your system...