I have not noticed any difference yet since upgrading to MV3.AdGuard Browser Extension 5.5.3.3
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Release v5.5.3.3 · AdguardTeam/AdguardBrowserExtension
In this release we’ve added AdGuard’s Manifest V3 (MV3) Browser Extension to Microsoft Edge. As of now, Manifest V2 (MV2) ad blockers no longer appear in Edge Add-ons search results. This is part o...github.com
But after the upgrade, my previously imported filters were not working. It was fixed after disabling the Custom option, enable it and then forcing a filter update.