Yes. I use it with KTS 2020 in two different computers. Just keep to the stable releases. The Nightly drivers sometimes creates problems.
That really depends on what you want Adguard to do. If it's just ad filtering then default is enough, although I normally increase how often it checks for filter updates. If you want it to help in privacy as well then activate stealth mode. It will automatically activate filters for other languages if you visit any site with a language it has a filter for.