My Vote goes to ESET, even if it's a paid suite.
Though I do prefer the Antivirus only (NOD32).
Detection - No comment, I use other methods and knowledge / common sense to avoid these situations.
Removal - No comment, I avoid getting infected in the first place.
Comodo uses scare-ware tactics on detection and removal for it's first time detection and new users, to lure them to use the GeekBuddy (ie. Installs more software).
Sandbox / BB / HIPS - Prefer not to use HIPS. I don't like the Auto-Sandbox initiated by the BB in Comodo.
UI - ESET has a simple and easy to use UI. Comodo releases new UI with every major release, there is no flow in their products.
RAM - Usage is a bit high for most, but it doesn't eat up the CPU (like experience from the cmdagent in Comodo). RAM shouldn't be an issue, if you have more than 2GB RAM.
Web Protection - ESET has Web protection to protect you from bad sites. Comodo is limited to their DNS service, which some may not like.
Anti-Theft - ESET has a new service called Anti-Theft for your PC (and mobile?)
Other Services - ESET released a new Social Scanner for your Facebook privacy and protection (which is free).