Question Does anybody know if indeed SAC can be turned on without reinstalling Windows?

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@devjitdutta2025

Affirmative. It's confirmed that the "sterile field" (Clean Install) requirement for Smart App Control (SAC) has been rescinded for Windows 11 versions 24H2 and 25H2.

While registry modifications (likely targeting the VerifiedAndReputablePolicyState) may now function due to this kernel-level policy shift, the official engagement protocol is exposed directly via the UI, navigate to Windows Security > App & Browser Control > Smart App Control to toggle enforcement.

Proceed with caution. Activating SAC on a "dirty" (previously used) system introduces a high probability of immediate "False Positives." Legitimate but unsigned binaries lacking global prevalence will be neutralized (blocked) by the automated Windows Defender Application Control (WDAC) policy. If your environment relies on custom tooling or niche software, anticipate significant operational friction.
 
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Yes.
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Notice the On/Off switches and no Evaluation Mode (greyed out).

@Parkinsond - no registry modification needed.
 
So indeed it seems that SAC now can be turned off safely and then re-enabled again without reinstalling the OS. Good job MS.
One good step, but a further one is needed.

I get blocked installer, I turn off SAC to finish installation, then turn SAC back on, then try to launch the app, then SAC blocks the app.
Exception will be a welcome addition.
 
How old is the installer? Is it fairly new?
Sometime SAC blocks the installer when freshly released, then allow it after days or weeks, as with media player classic.
Sometimes it blocks the installer even if old enough, as the case with peazip.

Sometimes it blocks the installer, but allows the installed app to launch; here turning off SAC is useful to bypass installation block.
Sometimes it blocks both the installer and the installed app after installation; turning off SAC will permit installation, but after turning it on again, launching app will be blocked.
 
One good step, but a further one is needed.

I get blocked installer, I turn off SAC to finish installation, then turn SAC back on, then try to launch the app, then SAC blocks the app.
Exception will be a welcome addition.

Sometime SAC blocks the installer when freshly released, then allow it after days or weeks, as with media player classic.
Sometimes it blocks the installer even if old enough, as the case with peazip.

Sometimes it blocks the installer, but allows the installed app to launch; here turning off SAC is useful to bypass installation block.
Sometimes it blocks both the installer and the installed app after installation; turning off SAC will permit installation, but after turning it on again, launching app will be blocked.
Submit through the Feedback Hub and wait a few days, then try again.

@Antimalware18 - what version Windows do you have? What region do you live in? It's probably another controlled rollout by MS.