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But back to your question - I've checked what will happened when we make denied user folder/folders...because of my Vista I've used to make deny whole folder "C:\Users\my_name\"...and actualy nothing interresting have happened with usual (installed) apps - it looks that they still work properly. Some interresting things I found when tried to install new app using .exe installator - in my case it was NVT OSArmor - insttalation process was broken with special system alert...see screenshot
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I attached some lines from log file of SS to show such issue
"2018-05-29 18:33:51,2192,C:\Moje programy\FreeCommander\FreeCommander.exe,53,Allowed ;Execution of an application ("C:\testy\unetbootin-windows-661.exe" )
2018-05-29 18:34:01,2192,C:\Moje programy\FreeCommander\FreeCommander.exe,53,Allowed ;Execution of an application ("C:\Users\xxx\AppData\Local\Temp\FreeCommander2192\2\CPix.exe" )
2018-05-29 18:34:01,4060,C:\Users\xxx\AppData\Local\Temp\FreeCommander2192\2\CPix.exe,50,Blocked ;Accessing the network via DNS Resolver service
2018-05-29 18:34:01,4060,C:\Users\xxx\AppData\Local\Temp\FreeCommander2192\2\CPix.exe,48,Blocked ;Outgoing network access
2018-05-29 18:34:15,4060,C:\Users\xxx\AppData\Local\Temp\FreeCommander2192\2\CPix.exe,26,Blocked ;Modifying protected registry key (HKLM\SOFTWARE\Classes\CPix.bmpfile\shell\open\command,)
2018-05-29 18:35:42,2000,C:\Windows\System32\taskeng.exe,53,Allowed ;Execution of an application (C:\Windows\system32\wermgr.exe -queuereporting)
2018-05-29 18:36:02,2192,C:\Moje programy\FreeCommander\FreeCommander.exe,53,Allowed ;Execution of an application ("C:\testy\osarmor_setup_1.4_test67.exe" )
2018-05-29 18:36:02,2964,C:\testy\osarmor_setup_1.4_test67.exe,53,Allowed ;Execution of an application ("C:\Users\xxx\AppData\Local\Temp\is-1CBGV.tmp\osarmor_setup_1.4_test67.tmp" /SL5="$220426,8243353,57856,C:\testy\osarmor_setup_1.4_test67.exe" )
2018-05-29 18:36:09,2448,C:\Users\xxx\AppData\Local\Temp\is-1CBGV.tmp\osarmor_setup_1.4_test67.tmp,26,Blocked ;Modifying protected registry key (HKLM\SYSTEM\ControlSet001\Control,ServicesPipeTimeout)"