Did you use the ConfigureDefender Log to see the issue?
Sure wish there was a way to talk to someone in person at MS. So frustrating. Hubby got a new iphone. His windows defender is blocking apple itunes. I and to uninstall it. It wouldnt install so I
answers.microsoft.com
It seems that it followed not from ConfigureDefender HIGH preset, but from Controlled Folder Acess which can be activated both via ConfigureDefender or Security Center.
Edit.
Controlled Folder Access (CFA) is not included in ConfigureDefender HIGH preset because it requires to make several exclusions for 3rd party applications (system optimizers, backup software, disk management, document editors, media management, etc.).