I think we should also define what is techie-user-friendly and what is average-user-friendly. Comodo is easy enough to use if you know your way around the concepts, but it is definitely not very easy for the average user. Real-world example: the desktop app of Copy.com couldn't update because Comodo's sandbox prevented it, since it didn't recognize the newly-downloaded updater as safe. In other words, any legitimate process that invokes a program unknown to Comodo (and that may range from the batch file customized with your video processing options called up by your video converter, your cloud storage option, etc etc) will have a high chance of failure. Some things just won't work as they should.
Having said that, on the other hand, if you install it for an average user who uses only apps from known companies (known and trusted by Comodo, that is, and they aren't few), then this shouldn't be a frequent problem.