I'd say Avast Free for protection. (Been protected with it alone for the past years..) Zemana Anti-Malware Free as a good on demand scanner. Smart surfing habits and you really do not need anything else.
I would just run Kaspersky Internet Security with Trusted Applications Mode turned on and call it a day, if anything gets by I doubt that ANY security solution would make a difference at all (except Shadow Defender and similars).
"Simplicity is the ultimate sophistication" and that is "even more true" when we are running Kaspersky.
KIS alone plus some good sense, that's more than enough to protect the average user. There's little to no gain in combining 4 security software. It can cause conflicts, slowdowns or cost more $$ than what is really needed. Maybe you could add ZAM, or VS or HMP, but they're not really necessary.
Looking lightweight and small hips .-), an independent not anti-exe. Yet freeware or lifetime license no comodo something small unassuming.Rehips also does not look bad either AppLocker but I wanted to just hips.